A research group led by Prof. Allen Liu at the University of Michigan, USA, used the ZEISS Lattice Lightsheet 7 to study cellular entry mechanisms of this virus. Using lattice light sheet imaging, they were able to visualize viral entry and how IAVs interact with epsin and clathrin at the plasma membrane.
Unlike traditional microscopy, lattice light sheet technique allowed us to visualize the viral entry on the entire cell surface. Furthermore, we were able to track IAVs before and after they attach to the cell membrane.
