New roles and applications in the areas of science and technology are continuously being found for synthetic polymers. As the applications of synthetic polymers increase, there is a need for methods to accurately and precisely characterize these materials. Here, we summarize two GPC applications developed on the all-in-one EcoSEC® GPC System. The system was used to monitor the synthesis and to quantify the oligomeric content of two PEGylated synthetic polymers and to measure the molar mass of an isocyanate modified polyurethane prepolymer in less than one hour.