TLC-MS is here and still evolving – continual advances in coupling techniques and ambient mass spectrometry are giving rise to a renaissance. Here, we share the most promising techniques and open your eyes to the powerful – and flexible – combinations of TLC and MS.
Hans Griesinger, Michael Schulz |
Over the last few years, several coupling techniques for mass spectrometry have emerged to broaden the scope of TLC-MS analysis beyond elution-based sampling. Though some ambient MS techniques were not developed specifically for TLC, they offer additional flexibility and a number of advantages. However, with choice comes the potential for confusion! We hope to shed light on what is available, comment on the level of “commercialization” or development, and also indicate the most appropriate choice, depending on your objective or application.
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