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Techniques & Tools Mass Spectrometry, Liquid Chromatography, Thin Layer Chromatography

State-of-the-Art TLC-MS

Over the last few years, several coupling techniques for mass spectrometry have emerged to broaden the scope of TLC-MS analysis beyond elution-based sampling. Though some ambient MS techniques were not developed specifically for TLC, they offer additional flexibility and a number of advantages. However, with choice comes the potential for confusion! We hope to shed light on what is available, comment on the level of “commercialization” or development, and also indicate the most appropriate choice, depending on your objective or application.

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About the Authors

Hans Griesinger

Analytical R&D Engineer, Merck Millipore, Germany.


Michael Schulz

Head of R&D Instrumental Analytics, Merck Millipore, Germany.

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