Zinc oxide is used in various skin care creams, drugs, and drug products.
USP has replaced the existing manual titration methods with ion chromatography method and has rewritten the General Chapter <591>.

The ion chromatography analysis involves separation of zinc oxide followed by post-column reaction using 4-(2-pyridylazo) resorcinol (PAR) reagent and subsequent detection at 530 nm wavelength. The new method is convenient to use and reliable and is approved by the FDA. Advantages of using Metrohm IC for zinc oxide assay:
- Precise software-controlled PCR delivery
- Simple reagent replenishment for easy use
- Automatic cleaning of the flow path
