Conexiant
Login
  • The Analytical Scientist
  • The Cannabis Scientist
  • The Medicine Maker
  • The Ophthalmologist
  • The Pathologist
  • The Traditional Scientist
The Analytical Scientist
  • Explore

    Explore

    • Latest
    • News & Research
    • Trends & Challenges
    • Keynote Interviews
    • Opinion & Personal Narratives
    • Product Profiles
    • App Notes

    Featured Topics

    • Mass Spectrometry
    • Chromatography
    • Spectroscopy

    Issues

    • Latest Issue
    • Archive
  • Topics

    Techniques & Tools

    • Mass Spectrometry
    • Chromatography
    • Spectroscopy
    • Microscopy
    • Sensors
    • Data and AI

    • View All Topics

    Applications & Fields

    • Clinical
    • Environmental
    • Food, Beverage & Agriculture
    • Pharma and Biopharma
    • Omics
    • Forensics
  • People & Profiles

    People & Profiles

    • Power List
    • Voices in the Community
    • Sitting Down With
    • Authors & Contributors
  • Business & Education

    Business & Education

    • Innovation
    • Business & Entrepreneurship
    • Career Pathways
  • Events
    • Live Events
    • Webinars
  • Multimedia
    • Video
Subscribe
Subscribe

False

The Analytical Scientist / App Notes / 2018 / SynthesisCell™ – Efficient Synthesis of Metabolites/ Degradants

SynthesisCell™ – Efficient Synthesis of Metabolites/ Degradants

08/13/2018

Share

Featured Image
Introduction

Recently, increased interest by Pharma and Academia has been shown in the use of electrochemical synthesis as an alternative technique to traditional enzymatic or wet chemical synthesis.

In one example, a key secondary metabolite M16 of the antimalarial drug Cipargamin (KAE609) under development by Novartis could be synthesised using the ROXY™ EC system equipped with SynthesisCell. For the first time ever, sufficient quantities could be synthesized, to allow full structural characterization by NMR, previously unable using traditional enzymatic techniques. In yet another example, fast and convenient electrochemical synthesis of pharmaceutical oxidation products (degradation products) of N-dealkylation reactions of Fesoterodine were successfully reported by Pfizer. The electrochemical procedure proved to be rapid, clean, and efficient compared to traditional synthetic methods and was particularly useful for generating milligram quantities of degradants. More information on the ROXY EC system and SynthesisCell can be found in the application note.


>> Download the full Application Note as PDF

Newsletters

Receive the latest analytical scientist news, personalities, education, and career development – weekly to your inbox.

Newsletter Signup Image

Explore More in Analytical Science

Dive deeper into the analytical science. Explore the latest articles, case studies, expert insights, and groundbreaking research.

False

Advertisement

Recommended

False

Related Content

Download the latest Lab Trends Report
Download the latest Lab Trends Report

January 8, 2018

To better understand the view from the lab, we asked nearly 500 scientists some searching questions...

Confocal Raman Imaging – Depth profiling of polymer films and coatings
Confocal Raman Imaging – Depth profiling of polymer films and coatings

January 16, 2018

This application note demonstrates how confocal Raman imaging is capable of acquiring depth profiles of polymers coatings that allow individual layers to be distinguished and measured...

Real-Time Speciation of Ethylbenzene from the Xylenes Using Direct MS
Real-Time Speciation of Ethylbenzene from the Xylenes Using Direct MS

January 18, 2018

This application note describes how selected ion flow tube mass spectrometry (SIFT-MS) readily achieves real-time speciation of the xylenes from ethylbenzene...

Monitoring and Controlling the Electrode Particle Characteristics and Viscosity of Battery Slurries
Monitoring and Controlling the Electrode Particle Characteristics and Viscosity of Battery Slurries

January 26, 2018

Using Morphologi G3 to monitor and control the electrode particle characteristics and viscosity of battery slurries...

False

The Analytical Scientist
Subscribe

About

  • About Us
  • Work at Conexiant Europe
  • Terms and Conditions
  • Privacy Policy
  • Advertise With Us
  • Contact Us

Copyright © 2025 Texere Publishing Limited (trading as Conexiant), with registered number 08113419 whose registered office is at Booths No. 1, Booths Park, Chelford Road, Knutsford, England, WA16 8GS.