HRMS DESI Imaging with the SELECT SERIES MRT Mass Spectrometer delivers enhanced mass accuracy and mass resolution compared to a conventional research grade oa-QToF mass spectrometer. The >200,000 FWHM mass resolution provided by the MRT mass spectrometer enables superior analyte detection and the <500 ppb mass accuracy improves putative biomarker identification.
Analysis of wild type murine adrenal gland tissue sections using a DESI-MRT Mass Spectrometer. Demonstrating the improvement in tissue analyte detection and identification using DESI on the MRT mass spectrometer, compared to a conventional oa-QToF Mass Spectrometer.
Mass Spectrometry based tissue imaging is a rapidly growing area of research seeing application in the life‑science, pharmaceutical, medical, and food sciences. Crucial to the success of this discipline is the ability to detect changes related to disease, toxicity, contamination, quality etc and to rapidly identify the resulting putative “biomarkers” of these changes. To this end improvements in the speed, mass resolution, and mass accuracy of mass spectrometry can greatly enhance efficiency and confidence for structural identification.
The SELECT SERIES MRT Mass Spectrometer is a Q-ToF mass spectrometer which possesses two gridless electrostatic mirrors, these allow the ion beam to under-go multiple reflections within the mass analyzer and extends the ion flight path to >48 meters equivalent. This gives mass accuracy (<500 ppb) and mass resolution (>200,000 FWHM), unprecedented in non-trapping instruments, with the advantage of also being unaffected by wide mass ranges or rapid scan speeds. This advancement has enabled high mass resolution capabilities for routine or large tissue imaging applications.
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