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The Analytical Scientist / App Notes / 2026 / Accurate characterization of silica slurries down to 15 nm by AF4-MALS coupled with ICP-MS

Accurate characterization of silica slurries down to 15 nm by AF4-MALS coupled with ICP-MS

08/18/2026

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Field-Flow Fractionation (FFF) comprises a family of techniques, which provide high-resolution separation of sample constituents in the size range from a few nanometers up to tens of microns [1]. Its most common subtype is Asymmetrical Flow FFF (AF4). AF4 hyphenated with Multi-Angle Light Scattering (MALS) and ICP-MS has proven to be a powerful analytical tool for the characterization of nanoparticle-containing samples enabling simultaneous access to size distribution as well as size-resolved elemental composition [2, 3]. 

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