Analysis of Monoclonal Antibody Digests with the Agilent 1290 Infinity 2D-LC Solution

contributed by Agilent Technologies | 02/18/2014

Protein biopharmaceuticals such as monoclonal antibodies and recombinant proteins are currently in widespread use for the treatment of various life-threatening diseases including cancer and autoimmune diseases. Protein therapeutics have a complexity far exceeding that of small molecule drugs, hence, unraveling this complexity represents an analytical challenge.

This Application Note demonstrates the potential of comprehensive two-dimensional liquid chromatography (LCxLC) using the Agilent 1290 Infinity 2D-LC Solution with DAD detection for the analysis of monoclonal antibody tryptic digests.

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