Techniques & Tools Sample Preparation, Liquid Chromatography, Mass Spectrometry, Forensics

Automated DBS-SPE-LC-MS/MS Analysis of Forensic and Veterinary samples

contributed by Gerstel | 02/20/2017

In this report, the complete automation of dried blood spot analysis is demonstrated and the results evaluated. A novel, automated DBS Autosampler (DBS A) automatically inserts DBS cards into a Flow Through Desorption (FTD^TM) cell in which individual blood spots are rapidly and effectively desorbed. The DBS A is integrated into a complete cleanup and analysis system using online SPE with replaceable cartridges combined with automated injection to an LC/MS/ MS system. Automated DBS extraction methods for a variety of analytes from different matrices are examined along with the use of different SPE cartridge sorbents. The resulting precision and accuracy data are provided.

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