Chromatographic reproducibility of the novel ionKey/MS System
contributed by Waters |
ionKey/MS: Enhanced MS with the turn of a Key. More sensitivity, more information from the same sample, more robust analysis. All with less solvent usage and less complexity to the user.
Goal
To evaluate chromatographic retention time and system reproducibility of Waters® ionKey/MS™ System.
Background
Chromatographic reproducibility is an essential requirement in any analytical laboratory environment. Parameters such as chromatographic retention time (RT), peak width (PW), peak tailing, and area counts are often monitored during system suitability testing before assays can begin on any liquid chromatography system. A critical component to obtaining highly reproducible LC-MS results is the consistent performance of the separations devices utilized. Chromatographic retention time reproducibility is not only dependent on the quality and consistency in the manufacturing of the separations devices, but is also effected by gradient formation, system pressure, flow rate and temperature control.
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