Correlation of FcR Affinity Chromatography with Glycan Pattern and ADCC Activity of a Therapeutic Antibody
contributed by Tosoh |
Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action (MoA) of monoclonal antibodies used in cancer treatment. Selecting suitable cell lines and optimizing culture conditions towards expression of antibody candidates with desired ADCC activity is an essential part of the R&D process. A fast and straight forward approach to easily access ADCC activity would facilitate screening of a large number of clones or monitoring the effect of upstream process variations. Other stages of R&D and production could benefit from fast ADCC assessment as well: comparing biosimilar and originator, detecting lot-to-lot variations, monitoring product stability, to name but a few.
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