Detection and quantitation of benzodiazepines in less than 3 min using PESI-MS

contributed by Shimadzu | 08/17/2023

Benzodiazepines (BZDs), which were the most prescribed medications globally in the 80s, remain frequently used as recreational drugs and are implicated in drug-facilitated sexual assaults or driving under influence of drugs cases. They are used for their anxiolytic, sedative, muscle relaxant and anticonvulsant properties. For that reasons, quantitative screening of BZDs is a routine work for emergency samples in a clinical toxicology context. Laboratories typically rely on immunochromatography (lateral flow test) or immunohistochemistry methods which quickly generate a result but often suffer from two major drawbacks:

numerous false negative results
only qualitative information

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