Evaluation of mAb ADCC Activity through Fc Receptor Affinity Chromatography

contributed by Tosoh | 02/19/2019

The N-glycans of antibody Fc domains are known to play an important role in Fc-mediated effector functions. Accordingly, separation patterns of therapeutic antibodies on TSKgel FcR-IIIA-NPR can be correlated to mAb glycoforms. Early eluting peaks (low affinity to Fc receptor) represent mAb glycoforms with low ADCC activity while late eluting peaks represent glycoforms with high ADCC activity.

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