Evaluation of Matrix Component Removal Using a Novel Flow-through Scavenging Plate for Drugs of Abuse Testing in Urine

contributed by Biotage | 06/19/2018

Dilute and shoot (D/S) is the most common form of sample preparation for the analysis of drugs of abuse in urine. High analyte cutoffs combined with sensitive mass spectrometers allow substantial sample dilution while still reaching desired limits of quantitation. However, this technique presents various issues resulting in increased MS downtime. This poster evaluates the extraction of a range of drugs of abuse from hydrolyzed and nonhydrolyzed urine using a novel flow-through matrix scavenging plate. Specific investigation of matrix component removal in terms of creatinine and urea, salt residue, pigmentation associated with urobillin content and protein removal will be demonstrated.

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