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Fast Extraction of Metanephrine and Norm etanephrine

This application note describes a method of extraction for metanephrine and normetanephrine from synthetic urine using EVOLUTE EXPRESS CX 96 fixed well plates.

Introduction
Figure 1. Structure of metanephrine and normetanephrine
Figure 1. Structure of metanephrine and normetanephrine

The normalized metabolite concentrations of epinephrine and norepinephrine precursors have common utility in clinical diagnostics related to neuroendocrine tumors. Of particular interest are the selected metabolites metanephrine and normetanephrine. The challenges in population screening for these metabolites are time, cost and efficacy of sample preparation strategies required for trace level determinations (pg/mL-ng/mL levels) by liquid chromatography-tandem mass spectrometry.

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