Highly sensitive targeted and non-targeted HPLC-MS analysis of PFAS

contributed by YMC | 02/27/2025

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants known for their long lifetime and mobility. Their stability leads to accumulation in groundwater and soil, with proven harmful health effects. To mitigate environmental pollution, several PFAS compounds, such as perfluorooctanoic acid (PFOA), perfluorohexanesulfonic acid (PFHxS), and long-chain perfluoroalkyl carboxylic acids (C9-C14), are now regulated.

This technical note presents a method for identifying and quantifying PFAS using a YMC-Triart C18 HPLC column. This column, based on a robust hybrid silica particle, offers enhanced separation of isomers and improved analytical performance when coupled with mass spectrometry.

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