How to Determine Extra Column Dispersion and Extra Column Volume

contributed by Ace | 11/21/2019

Introduction

The width of a chromatographic peak is dependent on various dispersion processes operating both inside and outside the column. Extra column volume (ECV) is an important source of extra column dispersion (ECD) and can have significant detrimental effects, resulting in losses in column efficiency and therefore peak resolution. This Knowledge Note outlines how ECV and ECD can be easily measured.

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