Impurity isolation and API purification by SFC

Scientists working on the purification of compounds by Supercritical Fluid Chromatography find this technique to be the right tool for managing the increasing sample workload submitted to them. This is due to two main reasons: personnel can carry out fast separations under SFC and drying the fractions collected is very quick.

Kromasil SFC columns have been developed for quick sample turnaround as the separations can take just a few minutes and are now being delivered in fused organosilane, cyano, diol, silica and 2-ethylpyridine chemistries to service the wide variety of mixtures that reach laboratories and kilo labs today. Because of the high surface availability of the Kromasil SFC line, the materials show great loadability which makes them excellent choices for preparative purification under overloaded conditions. Similarly to HPLC, almost all preparative separations using SFC start at analytical scale using either smaller particles or narrower columns, or a combination of the two. By developing the preparative method on an analytical scale, SFC users are able to minimize solvent and sample usage while minimizing time for method development.

>> Download the full Application Note as PDF

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