Microfluidic CE-MS: A Single System for Monitoring Small Molecule and Protein Biomarkers from Blood Samples

contributed by 908 Devices | 10/11/2018

Whole blood or purified blood cells are often analyzed in an effort to identify specific compounds that may be indicative of disease states. The compounds that are measured can range from small molecule metabolites to larger protein biomarkers.1,2 This necessitates the need for multiple pieces of instrumentation as there are few techniques capable of effectively analyzing both small and large molecules rapidly and simply. In this work we present a microfluidic CE-MS system capable of analyzing large and small molecule biomarkers without the need to significantly alter the instrumentation. The ZipChip^® microfluidic CE-MS interface coupled to Thermo mass spectrometers was used to analyze small molecule and protein based biomarkers from a variety of blood samples.

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