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The Analytical Scientist / App Notes / 2014 / Molecular weight cut-off determination for polysulfone membranes

Molecular weight cut-off determination for polysulfone membranes

03/21/2014

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Introduction

Polysulfone allows easy manufacturing of membranes, with reproducible properties and controllable pore sizes. These membranes are used for applications like haemodialysis, but also for waste water recovery or food and beverage processing. Cartridges made from polysulfone membranes offer extremely high flow rates at very low differential pressures.

pss logo

Polysulfone membranes are characterized by several characteristics:

  • Average pore size and pore size distribution
  • Molecular weight cut-off (MWCO)
  • Size selectivity
  • Filtration behavior
  • Sieve curve and retention efficiency
  • Binding or non-binding efficiency
  • Pore accessibility
  • Chemical, physical and biological stability
  • Hydrophobic properties
  • Fouling

With the exception of the last two, all of the listed properties can be determined easily with just one single filtration experiment followed by GPC/SEC characterization saving time and minimizing cost.1 GPC/SEC is a robust and fast method that can be easily established also in regulated laboratories needing to comply with GxP or FDA 21CFR11.

app note 3114 table 1
app note 3114-main img
>> Download the full Application Note as PDF

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