Multiple Heart-Cutting and Comprehensive 2D-LC Analysis of Biopharmaceuticals

contributed by Agilent Technologies | 12/01/2014

Online 2D-LC analysis of complex N-Glycans for highest resolution using the Agilent 1290 Infinity 2D-LC solution.

Erythropoietin (EPO) is a 30400 dalton (Da) glycoprotein hormone that regulates the production of red blood cells (erythropoiesis). The glycosylation of EPO is highly variable because it contains multiple glycosylation sites, each of which can have a wide variety of glycan structures. This results in a huge complexity of glycan structures that is referred to as microheterogeneity.

Recombinant human EPO (rhEPO) has proven to be highly efficient in the treatment of different diseases such as anemias associated with cancer, chronic renal failure and HIV infection.

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