Fields & Applications Clinical, Mass Spectrometry

New Research Evaluating Cisplatin Uptake in Ovarian Cancer Cells by Single Cell ICP-MS

contributed by Perkin Elmer | 05/08/2017

Cisplatin, carboplatin, and oxaliplatin are the most widely used of platinumbased cancer chemotherapy drugs in the Western world. Cisplatin's effectiveness is due to its ability to bind to the DNA, resulting in DNA-platinum (Pt) adducts, which bend the DNA. The cells must then repair the DNA damage, otherwise DNA replication is blocked resulting in cell death¹.

Many cancers are initially sensitive to platinum-based treatment, but patients frequently relapse with tumors displaying resistance to further cisplatin therapy1. Cisplatin drug resistance is due to three major molecular mechanisms: increased DNA repair, increased cytosolic inactivation, and altered cellular accumulation. Decreased cellular uptake or increased cellular export of cisplatin constitutes the mechanisms involved in altered cellular accumulation¹.

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