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Reaction monitoring of Antibody-Drug-Conjugates (ADCs) Using YMC´s BioPro HIC BF

Drug-antibody ratio (DAR) of antibody-drug conjugates (ADCs) is important for their therapeutic efficacy and pharmacokinetics. Therefore control of DAR in the synthesis process is a key for ADC quality control. The ability to monitor this step reliably can also be advantageous for process understanding and control.

To provide a solution for this approach, RIKEN, the Japanese National Research and Development Agency successfully developed a method involving hydrophilic interaction chromatography (HIC) linked to UV/Vis spectroscopy (see table 1).

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