Cookies

Like most websites The Analytical Scientist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.

Reaction monitoring of Antibody-Drug-Conjugates (ADCs) Using YMC´s BioPro HIC BF

Drug-antibody ratio (DAR) of antibody-drug conjugates (ADCs) is important for their therapeutic efficacy and pharmacokinetics. Therefore control of DAR in the synthesis process is a key for ADC quality control. The ability to monitor this step reliably can also be advantageous for process understanding and control.

To provide a solution for this approach, RIKEN, the Japanese National Research and Development Agency successfully developed a method involving hydrophilic interaction chromatography (HIC) linked to UV/Vis spectroscopy (see table 1).

Read the full article now

Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE and always will be!

Login

Or register now - it’s free and always will be!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Analytical Scientist magazine
Register

Or Login via Social Media

By clicking on any of the above social media links, you are agreeing to our Privacy Notice.

Newsletter

Send me the latest from The Analytical Scientist.

Sign up now

Related Articles

Techniques & Tools Micro/Nano-scale

Model Body Building

| Sabeth Verporte, Maarten Honing, Jaap den Toonder, Edmond Young

Techniques & Tools Spectroscopy

The Color of Chirality

| Maryam Mahdi

Techniques & Tools Spectroscopy

Breaking into Bio-medicine with Raman

| Wei Min

Register to The Analytical Scientist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Analytical Scientist magazine

Register