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Streamlined Sample Preparation of a Drugs of Abuse Panel in Human Nails Using ISOLUTE® SLE+ Prior to UPLC-MS/MS Analysis

Introduction

The testing of alternative matrices in forensic and/or clinical toxicology is gaining popularity, partly due to less invasive means of collection. Matrices such as hair or nail can provide a more rounded picture of abstinence or abuse and associated timeframes. This application note describes the sample pre-treatment and subsequent extraction of 49 drugs of abuse from human nails, prior to LC/MS analysis.

The method utalizes Biotage® Lysera for matrix micropulverisation, prior to direct transfer to clean up using ISOLUTE® SLE+ supported liquid extraction products. Elimination of an evaporation step between the micropulverisation and supported liquid extraction clean up stages provides a streamlined procedure for nail extraction.

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