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The Power of Stationary Phase Selectivity

ABSTRACT

Method development is a process to select the chromatographic conditions best suited to obtain adequate separation of an analyte mixture. One of the key parameters in the method developers toolkit is stationary phase selectivity. Stationary phase chemistry can influence the mechanisms of interactions with analytes, thereby offering potential selectivity differences. This ACE Knowledge Note will briefly look at what selectivity means and the different reversed-phase interactions.

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