Antibody Analysis for Avian Influenza
New device offers a 20-minute test to detect virus antibodies
Luke Turner |
A new portable analyzer can detect anti-avian influenza antibodies in blood serum in just 20 minutes (1). The technology, which consists of liquid crystal molecules, an image sensor, and a microfluidic device, rapidly indicates antibody presence and weighs only 5.5 kg. The researchers who conceived it also developed an accompanying fluorescein-labeled protein reagent, which binds only to the anti-H5 avian influenza antibody.
To conduct the test, serum and reagent are mixed for 15 minutes, then injected into the microfluidic device and measured by a portable fluorescence polarization analyzer. Samples containing bound antibodies and reagent create smaller molecular movements, producing a different degree of polarization. Could the test also be used against COVID-19? “By reproducing fragments of spike proteins expressed in the novel coronavirus to use as the reagent, the analyzer should be able to detect anti-coronavirus antibodies,” said Hokkaido University’s Manabu Tokeshi (2).
Enjoy our FREE content!
Log in or register to gain full unlimited access to all content on the The Analytical Scientist site. It’s FREE and always will be!
Or register now - it’s free and always will be!
You will benefit from:
- Unlimited access to ALL articles
- News, interviews & opinions from leading industry experts
- Receive print (and PDF) copies of The Analytical Scientist magazine
Or Login via Social Media
By clicking on any of the above social media links, you are agreeing to our Privacy Notice.
- K Nishiyama et al., Sens Actuators B Chem, 316 (2020). PMID: 32322135.
- Hokkaido University (2020). Available at: https://bit.ly/3i82hXk.