Charting a Course to Lipidomics Success
Researchers use ion mobility-mass spectrometry to create a "lipid atlas."
Ryan De Vooght-Johnson | | Quick Read
Lipids are involved in a wide range of biological processes and implicated in numerous diseases, but their complex structures can challenge conventional mass spectrometry techniques. Now, chemists from Vanderbilt University have advanced lipid research using high-precision ion mobility coupled to mass spectrometry (IM-MS) (1, 2).
Read the full article now
Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE and always will be!
Or register now - it’s free and always will be!
You will benefit from:
- Unlimited access to ALL articles
- News, interviews & opinions from leading industry experts
- Receive print (and PDF) copies of The Analytical Scientist magazine
Or Login via Social Media
By clicking on any of the above social media links, you are agreeing to our Privacy Notice.
- KL Leaptrot et al., “Ion mobility conformational lipid atlas for high confidence lipidomics”, Nat Commun, 10 [Epub ahead of print] (2019). DOI: 10.1038/s41467-019-08897-5.
- H Hall, Vanderbilt University, “New lipid shape atlas holds key to early disease detection” (2019). Available at: bit.ly/2TMAkuA. Accessed March 12, 2019.
- JC May et al., “Conformational ordering of biomolecules in the gas phase: nitrogen collision cross sections measured on a prototype high resolution drift tube ion mobility-mass spectrometer”, Anal Chem, 86, 2107–2116 (2014). DOI: 10.1021/ac4038448.
- McClean Research Group, “Unified CCS Compendium” (2019). Available at: bit.ly/2O0fPFB. Accessed March 12, 2019
- JA Picache et al., “Collision cross section compendium to annotate and predict multi-omic compound identities”, Chem Sci, 10, 983-993 (2019). DOI: 10.1039/C8SC04396E
- JC May et al., “Ion mobility collision cross section compendium”, Anal Chem, 89 (2) 1032-1044 (2017). DOI: 10.1021/acs.analchem.6b04905