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Fields & Applications Metabolomics & Lipidomics, Mass Spectrometry

Charting a Course to Lipidomics Success

Lipids are involved in a wide range of biological processes and implicated in numerous diseases, but their complex structures can challenge conventional mass spectrometry techniques. Now, chemists from Vanderbilt University have advanced lipid research using high-precision ion mobility coupled to mass spectrometry (IM-MS) (1, 2).

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  1. KL Leaptrot et al., “Ion mobility conformational lipid atlas for high confidence lipidomics”, Nat Commun, 10 [Epub ahead of print] (2019). DOI: 10.1038/s41467-019-08897-5.
  2. H Hall, Vanderbilt University, “New lipid shape atlas holds key to early disease detection” (2019). Available at: bit.ly/2TMAkuA. Accessed March 12, 2019.
  3. JC May et al., “Conformational ordering of biomolecules in the gas phase: nitrogen collision cross sections measured on a prototype high resolution drift tube ion mobility-mass spectrometer”, Anal Chem, 86, 2107–2116 (2014). DOI: 10.1021/ac4038448.
  4. McClean Research Group, “Unified CCS Compendium” (2019). Available at: bit.ly/2O0fPFB. Accessed March 12, 2019
  5. JA Picache et al., “Collision cross section compendium to annotate and predict multi-omic compound identities”, Chem Sci, 10, 983-993 (2019). DOI: 10.1039/C8SC04396E
  6. JC May et al., “Ion mobility collision cross section compendium”, Anal Chem, 89 (2) 1032-1044 (2017). DOI: 10.1021/acs.analchem.6b04905

About the Author

Ryan De Vooght-Johnson

After graduating from the University of Warwick with a masters in instrumental and analytical methods for biological, pharmaceutical, and environmental chemistry, I worked in the laboratory in various analytical development roles. I was then lucky to find my calling in academic publishing and science writing. I’ve been a commissioning editor and launch editor in a biomedical publisher and since 2014, I’ve been working as a freelance science writer and editor.

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