Charting a Course to Lipidomics Success
Researchers use ion mobility-mass spectrometry to create a "lipid atlas."
Ryan De Vooght-Johnson | | Quick Read
Lipids are involved in a wide range of biological processes and implicated in numerous diseases, but their complex structures can challenge conventional mass spectrometry techniques. Now, chemists from Vanderbilt University have advanced lipid research using high-precision ion mobility coupled to mass spectrometry (IM-MS) (1, 2).
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- KL Leaptrot et al., “Ion mobility conformational lipid atlas for high confidence lipidomics”, Nat Commun, 10 [Epub ahead of print] (2019). DOI: 10.1038/s41467-019-08897-5.
- H Hall, Vanderbilt University, “New lipid shape atlas holds key to early disease detection” (2019). Available at: https://bit.ly/2TMAkuA. Accessed March 12, 2019.
- JC May et al., “Conformational ordering of biomolecules in the gas phase: nitrogen collision cross sections measured on a prototype high resolution drift tube ion mobility-mass spectrometer”, Anal Chem, 86, 2107–2116 (2014). DOI: 10.1021/ac4038448.
- McClean Research Group, “Unified CCS Compendium” (2019). Available at: https://bit.ly/2O0fPFB. Accessed March 12, 2019
- JA Picache et al., “Collision cross section compendium to annotate and predict multi-omic compound identities”, Chem Sci, 10, 983-993 (2019). DOI: 10.1039/C8SC04396E
- JC May et al., “Ion mobility collision cross section compendium”, Anal Chem, 89 (2) 1032-1044 (2017). DOI: 10.1021/acs.analchem.6b04905