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Fields & Applications Mass Spectrometry, Spectroscopy, Metabolomics & Lipidomics, Forensics, Food, Beverage & Agriculture, Pharma & Biopharma

Landmark Literature: Part II

The Shape of Things to Come

By Koen Sandra, Scientific Director, Research Institute for Chromatography, Kortrijk, Belgium; co-founder and R&D Director anaRIC biologics, Ghent, Belgium.

It will come as no surprise that my selected paper is related to biopharmaceutical analysis. Biopharmaceuticals are becoming a core aspect of the pharmaceutical industry and, in recent years, we have observed many advances in the analysis of these huge and complex structures. 2017 saw a number of exciting papers and lectures in the field – a few that spring to mind are:

  • Four-dimensional liquid chromatography (4D-LC) in hyphenation to mass spectrometry (MS) for the characterization of monoclonal antibodies (mAbs) (1);
  • Detailed characterization of the glycosylation profile of the fusion protein etanercept by high-resolution native MS (2);
  • Hydrophilic interaction chromatography (HILIC) for the separation of mAbs at middle-up level (3);
  • Direct coupling of cation exchange chromatography (CEX) to MS to directly assign a molecular weight (MW) value to acidic and basic variants of mAbs (4).

Arsenic: an Old Trace

By Julian Tyson, Emeritus Professor Analytical Chemistry, University of Massachusetts, Amherst, USA.

Latent Talents

By Christopher C. Mulligan, Professor of Analytical Chemistry, Department of Chemistry, Illinois State University, USA.

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About the Authors

Koen Sandra

Koen Sandra is R&D Director Life Sciences and Metablys, Research Institute for Chromatography, Kortrijk, Belgium.

Liam Heaney

Dr Liam Heaney is a postdoctoral researcher at the University of Leicester’s NIHR Cardiovascular Biomedical Research Unit, working in the John and Lucille van Geest Biomarker Facility. Liam is a senior member of the Cardiovascular Translational Research Group headed by consultant cardiologist Professor Toru Suzuki, where he specialises in the analysis of cardiovascular disease biomarkers using non-targeted/discovery and targeted LC-MS-based metabolomics. Previously, Liam attended Loughborough University where he was awarded his BSc in Sport & Exercise Science, MSc in Exercise Physiology and later his PhD in Analytical Chemistry, using GC-MS techniques to produce a thesis entitled ‘Exhaled Breath Analysis in Exercise and Health’.

Julian Tyson

Julian Tyson, Professor Emeritus of Chemistry at the University of Massachusetts, Amherst, received his B.S. in Chemistry from Aberdeen University in Scotland in 1971, and his Ph.D. in Analytical Chemistry from Imperial College, London University in England in 1975. He was a faculty member at Loughborough University, in the UK for 13 years, before relocating to UMass in 1989.

Julian is an analytical chemist whose current interests are focused on the bio- geo- and environmental chemistry of arsenic compounds and the associated chemical measurement challenges. He has been associated with the work of Chemists Without Borders since the fall of 2014. He is currently the manager of the Arsenic-in-Rice Project.

Christopher Mulligan

Associate Professor, Illinois State University.

Vassilia Zorba

Group Leader, Lawrence Berkeley National Laboratory, Berkeley, California, USA.

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