Cookies

Like most websites The Analytical Scientist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Fields & Applications Metabolomics & Lipidomics

Metabolomics: the Superglue of Omics

Our understanding of cellular and molecular processes has increased exponentially during the last century. Several key questions about the function of our cells and, to a broader extent, their interactions with entire organisms have been answered, with the most prominent findings being the elucidation of our DNA structure and the sequencing of the human genome (1). The key outcome of 20th century biomedical and biological research was the knowledge we gained about the coding, content and flow of information within our cells and body. The concept that our cells contain our hereditary information in the form of DNA, which is transcribed into RNA and translated into proteins that are ultimately involved in the modulation of our metabolome is the central dogma of biology, and a comprehensive understanding of this process represents the fundamental goal of omics technologies (2).

But beyond a better understanding of ourselves, what has been the impact of these findings and technologies on our lives? Genomics (DNA sequencing) has certainly enhanced diagnosis and treatment of inborn errors and hereditary diseases. Transcriptomics (the analysis of RNA transcripts) complements genomics by allowing us to decipher gene expression, again helping to identify undiagnosed cases of genetic diseases. Proteomics (the comprehensive analysis of an organism’s proteins) would ideally complement genomics and transcriptomics; however, several ongoing analytical challenges are still hampering comprehensive protein analysis. Nevertheless, we believe advances in proteomics happening today will allow for a more efficient use of proteomics tomorrow, so that it may become a complementary diagnostic approach to other omics techniques (3).

Read the full article now

Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE and always will be!

Login

Or register now - it’s free and always will be!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Analytical Scientist magazine
Register

Or Login via Social Media

By clicking on any of the above social media links, you are agreeing to our Privacy Notice.

About the Authors

Martin Giera

Martin Giera studied pharmacy in Heidelberg and Munich. He is currently the head of the Metabolomics group at the Center for Proteomics and Metabolomics at the Leiden University Medical Center (LUMC). He holds a PhD in Pharmaceutical Chemistry obtained from the Ludwig-Maximilians-University in Munich (Germany) under the supervision of Prof. Franz Bracher. With a postdoctoral fellowship, he joined the group of Prof. Hubertus Irth at the VU University Amsterdam where he later became Assistant Professor and head of the Bioanalysis group. Following a research stay in the laboratory of Prof. Charles Serhan at Harvard Medical School, he moved to the LUMC where he today heads the Metabolomics group. His main interests lie in clinical and fundamental disease-related research, using metabolomics-based approaches and notably lipidomics.


Mary E. Spilker

Mary E. Spilker is Associate Research Fellow at Pfizer Worldwide Research and Development and is currently a visiting scientist at the Scripps Center for Metabolomics at the Scripps Research Institute, La Jolla, California, USA.


Gary Siuzdak

Gary Siuzdak is Professor and Director of the Scripps Center for Metabolomics at the Scripps Research Institute, La Jolla, California, USA.

Newsletter

Send me the latest from The Analytical Scientist.

Sign up now

Register to The Analytical Scientist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Analytical Scientist magazine

Register