µPAC in Practice – Part I
By Pat Sandra, Emeritus Professor, Organic Chemistry, Ghent University; Founder and President, Research Institute for Chromatography, Kortrijk, Belgium.
Pat Sandra |
It is well documented that miniaturization of the separation medium offers several advantages for high-resolution LC-MS analysis of complex samples, such as those encountered in proteomics, metabolomics, and biopharmaceutical characterization. The inherent high permeability and low on-column dispersion obtained by the perfect order of the separation bed in micro-pillar array columns (µPAC) is superior to packed beds and monoliths for high-resolution separations. We have recently illustrated this in a number of applications using the first generation of commercially available µPAC to analyze biopharmaceuticals using µPAC combined with mass spectrometry (µPAC-MS), described below. Moreover, the µPAC concept can in the future be tuned and optimized for production of separation media with unique features for high throughput and high productivity applications as well … to follow!
µPAC in Practice – Part II
An interview with Goran Mitulović, Head of the Proteomics Core Facility at the Medical University of Vienna, Austria.
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