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Fields & Applications Pharma & Biopharma

µPAC in Practice – Part I

It is well documented that miniaturization of the separation medium offers several advantages for high-resolution LC-MS analysis of complex samples, such as those encountered in proteomics, metabolomics, and biopharmaceutical characterization. The inherent high permeability and low on-column dispersion obtained by the perfect order of the separation bed in micro-pillar array columns (µPAC) is superior to packed beds and monoliths for high-resolution separations. We have recently illustrated this in a number of applications using the first generation of commercially available µPAC to analyze biopharmaceuticals using µPAC combined with mass spectrometry (µPAC-MS), described below. Moreover, the µPAC concept can in the future be tuned and optimized for production of separation media with unique features for high throughput and high productivity applications as well … to follow!

µPAC in Practice – Part II

An interview with Goran Mitulović, Head of the Proteomics Core Facility at the Medical University of Vienna, Austria.

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About the Author

Pat Sandra

Pat Sandra is Emeritus Professor of Organic Chemistry at Ghent University, and Founder and President of the Research Institute for Chromatography (RIC), Kortrijk, Belgium. “Through the activities of RIC, I got in touch with the real analytical needs of the industry and found we could help in providing solutions that are economically relevant. Moreover, it allowed me to keep my best PhD students around me, which resulted in high scientific output in a non-academic environment,” he says.

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