Raman in the Clinic
Ananya Barui discusses the potential – and pitfalls – of Raman spectroscopy in the clinic
Jonathan James | | Interview
What’s the focus of your work?
The goal of my group at the Indian Institute of Engineering Science and Technology in Shibpur is to develop effective diagnostic tools for early cancer detection. Despite histopathological methods being the clinical gold standard, their invasive nature prevents real-time disease monitoring – a clear objective for pathologists worldwide.
We’ve started collecting exfoliated cells from susceptible regions of oral and cervical tissues, and are analyzing these using different modes of quantitative microscopy. The evaluation of collected samples using Fourier-transform infrared (FTIR) spectroscopy provides useful information about alterations in cellular functional groups, strengthening our screening processes; capitalizing on the complementary nature of Raman and FTIR spectroscopy then allows us to give our measurements higher sensitivity and specificity.
We’re now trying to incorporate advanced chemometric techniques into our workflows to aid in data analysis. The aim: development of a label-free cancer prediction system. We want to explore the application of surface-enhanced Raman scattering in label-free genomic and transcriptomic biomarker detection for stratifying epithelial cancers by stage.
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