Raman on the Brain
An enhanced spectroscopic approach could be the answer to Alzheimer’s biomarker detection
Lauren Robertson |
Despite a large research effort in recent decades, early diagnosis of Alzheimer’s disease (AD) remains challenging. AD biomarkers have proven invaluable, but we still need a sensitive and cost-effective method to detect them. Now, researchers have shown that fiber-enhanced Raman spectroscopy (FERS) could help overcome the limitations of traditional spectroscopic methods and enable reliable detection of amyloid β-peptide – a major AD biomarker (1).
The approach involves integrating a hollow-core photonic crystal fiber with conventional Raman spectroscopy and coupling this to surface-enhanced Raman spectroscopy. This enabled the researchers to amplify the weak biomarker Raman signal more than 200-fold. Further research is planned, but the approach takes us one step closer to early AD diagnosis.
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- PJ Eravuchira et al., J Biomed Optics, 25, 077001 (2020). DOI: 10.1117/1.JBO.25.7.077001