Resolution Revolution Realized
Breakthroughs in cryo-electron microscopy provide atomic-level protein information that may transform drug development
Jonathan James | | Quick Read
Atomic-level structural resolution has driven major breakthroughs in drug development by gifting pharmacologists with ever-increasing knowledge of potential drug targets. Cryo-electron microscopy (cryo-EM) represents a valuable tool for extracting this information, rivalling classic techniques like X-ray crystallography and earning Jacques Dubochet, Joachim Frank and Richard Henderson the Nobel Prize in Chemistry in 2017 for their work laying the foundations for this technique in the high-resolution structural determination of biomolecules.
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