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Fields & Applications Spectroscopy, Metabolomics & Lipidomics

Search for the Unknown

Getting to know our metabolomes is tricky. We have to contend with a high diversity of molecular structures and concentrations, as well as a lack of standardized or automated methods for data collection and reporting. But a team of researchers think they can help (1).

Their multidimensional platform for identifying NMR-generated biomarkers involves eight different steps – from statistical spectroscopic tools and two-dimensional NMR analysis to separation techniques like solid-phase extraction. Although the full protocol can take up to a month, an alternative approach with fewer steps could take just two or three days to perform. This could not only speed up metabolic phenotyping studies, but also offer a cost-effective and efficient way to cover more of the metabolome.

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  1. I Garcia-Perez et al., Nature Protocols, 15, 2538 (2020). DOI: 10.1038/s41596-020-0343-3
About the Author
Lauren Robertson

By the time I finished my degree in Microbiology I had come to one conclusion – I did not want to work in a lab. Instead, I decided to move to the south of Spain to teach English. After two brilliant years, I realized that I missed science, and what I really enjoyed was communicating scientific ideas – whether that be to four-year-olds or mature professionals. On returning to England I landed a role in science writing and found it combined my passions perfectly. Now at Texere, I get to hone these skills every day by writing about the latest research in an exciting, creative way.

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