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Techniques & Tools Spectroscopy, Chemical

The Tag Team

Overtaking CARS

As a postdoc, I co-invented stimulated Raman scattering (SRS) microscopy for imaging chemical bonds (1). At that time, the Raman imaging field was dominated by coherent anti-Stokes Raman scattering (CARS) microscopy, but the high background and poor spectral fidelity of CARS meant there was a lot of “in-fighting” within the field. Rather than getting trapped in the CARS swamp, in 2008 I proposed SRS, another spectroscopic process for imaging. SRS quickly superseded CARS as the best method, and my cofirstauthored paper was cited more than 1,200 times.

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  1. CW Freudiger et al., Science, 322, 1857 (2008).
  2. L Wei et al., Nature Methods, 11, 410 (2014).
  3. L Wei et al., Proc Natl Acad Sci USA, 110, 11226 (2013).
  4. Y Shen et al., Proc Natl Acad Sci, 114, 13394 (2017).
  5. Y. Shen et al., Angew Chemie Int Ed Engl, 53, 5596 (2014).
  6. L Wei et al., Acc Chem Res, 49, 1494 (2016).
  7. JW Lichtman, W Denk, Science, 334, 618 (2011).
  8. L Wei et al., Nature, 544, 465 (2017).
  9. L Wei, W Min, J Phys Chem Lett, 9, 4294 (2018).
  10. F Hu et al., Nat Methods 15, 194 (2018).
  11. L Shi et al., Nat Commun, 9, 2995 (2018).
  12. K Schiessl et al., Nat Commun, 15, 10 (2019).
  13. PJ Jones, ST Leatherdale, Clin Sci, 80, 277 (1991).
  14. Q Cheng et al., Nat Commun, 9, 2942 (2018)

About the Author

Wei Min

Professor, Department of Chemistry, Kavli Institute for Brain Science, Columbia University, New York, USA.

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