Like most websites The Analytical Scientist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Subscribe to Newsletter
Fields & Applications Mass Spectrometry, Clinical

Writing Off Cancer

Meet the MasSpec Pen, a handheld mass spectrometry device with the potential to speed up accurate and intraoperative diagnosis of human cancer. The pen – which releases a water droplet onto suspected cancer tissue before drawing it back up for chemical analysis – was able to predict cancer with high sensitivity (96.4 percent), specificity (96.2 percent), and an overall accuracy of 96.3 percent (1).

Finding and removing the edges of cancerous tissue by sight alone is a particular challenge for surgeons, and successful resection of all the cancerous tissue clearly has huge health implications for the patient. The resulting demand for precise, accurate and rapid detection has already inspired one similar device: the electrosurgical iKnife, which uses rapid evaporative ionization mass spectrometry (REIMS; see here).

The MasSpec Pen was conceived two years ago by Livia Schiavinato Eberlin, Assistant Professor, Department of Chemistry, University of Texas at Austin (notably, one of The Analytical Scientist’s Top 40 Under 40) – but for this small, yet seemingly mighty technology, it is only the beginning.

“We are going to further validate the technology in my lab with larger sample sets and expand to other cancer types – then we’ll start testing in surgeries with our colleagues in the Texas Medical Center to compare our results with current results from clinical practice,” says Eberlin. “Next we should expand to larger clinical trials to really prove that the technology can improve surgical treatment and patient care.” Eberlin and team hope to be able to trial the device during operations within the next 12 months.

Eberlin says it is very rewarding to work on a project with such high potential impact. “Since working with R. Graham Cooks during my PhD, the last 10 years of my career have been dedicated to translational and clinical research, and I am excited about the recent development of the MasSpec Pen,” she says. “I am very passionate about the field, and specifically about developing mass spectrometry technology that can make a real difference in clinical practice. My amazing research team and I have been working extremely hard on this project. It is amazing to see what they have accomplished so quickly!”

Receive content, products, events as well as relevant industry updates from The Analytical Scientist and its sponsors.
Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

  1. J Zhang et al., “Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system”, Sci Transl Med, 9, eaan3968 (2017).
About the Author
Joanna Cummings

A former library manager and storyteller, I have wanted to write for magazines since I was six years old, when I used to make my own out of foolscap paper and sellotape and distribute them to my family. Since getting my MSc in Publishing, I’ve worked as a freelance writer and content creator for both digital and print, writing on subjects such as fashion, food, tourism, photography – and the history of Roman toilets. Now I can be found working on The Analytical Scientist, finding the ‘human angle’ to cutting-edge science stories.

Related Application Notes
Analytical Solutions for Analysis of Polymer Additives

| Contributed by Shimadzu

Characterization of MAbs Using FcR-Affinity and HILIC-MS

| Contributed by Tosoh

A Fast and Robust GC/MS/MS Analysis of 203 Pesticides in 10 Minutes in Spinach

| Contributed by Agilent Technologies

Related Product Profiles
Higher Peaks – Clearly.

| Contributed by Shimadzu Europa

Compact with countless benefits

| Contributed by Shimadzu Europa

The fine Art of Method Development

| Contributed by Shimadzu Europa

Register to The Analytical Scientist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Analytical Scientist magazine