A new article from Malvern Instruments provides practical guidance on using automated particle image analysis to detect agglomerates in pharmaceutical formulations. Particle agglomeration has the potential to compromise clinical efficacy and must therefore be closely monitored and controlled during manufacture. Experimental data illustrate different strategies for the detection of agglomerates on the basis of size, shape and, where necessary, chemical identification. Compared with manual microscopy, automated imaging is fast, statistically reliable and cost efficient, making it a valuable tool for product development, process troubleshooting and QC.
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Malvern provides the materials and biophysical characterization technology and expertise that enables scientists and engineers to investigate, understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries. Used at all stages of research, development and manufacturing, Malvern’s instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency. Our products reflect Malvern’s drive to exploit the latest technological innovations. They are used by both industry and academia, in sectors ranging from pharmaceuticals and biopharmaceuticals to bulk chemicals, cement, plastics and polymers, energy and the environment. Malvern systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications. www.malvern.com Material relationships http://www.malvern.com/en/ [email protected]
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