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The Analytical Scientist / Issues / 2024 / Aug / The Quantum Guardian
Spectroscopy Clinical

The Quantum Guardian

Researchers discover a new biological quantum effect that could improve Alzheimer’s treatment – using steady-state spectroscopy

By James Strachan 08/06/2024 1 min read

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Quantum biology explores the role of quantum mechanics in biological processes. Quantum effects – like electron tunneling, coherence, and entanglement – have been observed in some biological molecules and may play a role in olfaction and certain enzymatic reactions. 

Recently, researchers have discovered a new biological quantum effect: ultraviolet superradiance from mega-networks of tryptophan in neurons (1). The team at the Quantum Biology Laboratory, Howard University, USA, found that when many tryptophan (Trp) molecules are arranged in a symmetrical network, they fluoresce stronger and faster than they would if they were fluorescing independently – thanks to quantum mechanics. 

The key to this discovery? Steady-state spectroscopy analysis of the microtubules (MTs) – representing mesoscale networks of Trp residues. “It took very precise and careful application of standard protein spectroscopy methods, but guided by the theoretical predictions of our collaborators, we were able to confirm a stunning signature of superradiance in a micron-scale biological system,” said co-author Majed Chergui in a press release (2). 

Interestingly, because tryptophan mega-networks can absorb the damaging UV light emitted by free radicals more efficiently than independently fluorescing tryptophan. This quantum effect could be advanced to a protective strategy against diseases associated with oxidative stress, such as Alzheimer’s disease.

“This photoprotection may prove crucial in ameliorating or halting the progression of degenerative illness,” said Kurian. “We hope this will inspire a range of new experiments to understand how quantum-enhanced photoprotection plays a role in complex pathologies that thrive on highly oxidative conditions.”

Credit: Collage created using Adobe Stock images

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References

  1. NS Badcock et al., J. Phys. Chem. B, 128, 17 (2024). DOI: doi.org/10.1021/acs.jpcb.3c07936  
  2. Quantum Biology Laboratory (2024). Available at:  https://bit.ly/45BUPg3 

About the Author(s)

James Strachan

Over the course of my Biomedical Sciences degree it dawned on me that my goal of becoming a scientist didn’t quite mesh with my lack of affinity for lab work. Thinking on my decision to pursue biology rather than English at age 15 – despite an aptitude for the latter – I realized that science writing was a way to combine what I loved with what I was good at. From there I set out to gather as much freelancing experience as I could, spending 2 years developing scientific content for International Innovation, before completing an MSc in Science Communication. After gaining invaluable experience in supporting the communications efforts of CERN and IN-PART, I joined Texere – where I am focused on producing consistently engaging, cutting-edge and innovative content for our specialist audiences around the world.

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