Taking the Rough with the Smooth
Researchers at the Max Planck Institute for Chemical Ecology have developed a new mass spectrometry imaging technique for reliable chemical analysis of rippled, hairy, bulgy or coarse surfaces. Laser ablation electrospray ionization (LAESI) uses a mid-infrared laser to generate vapor from the sample, which is then ionized by the electrospray source and analyzed in the mass spec. Here, their custom-built laser source is used to analyze the surface of a savoy cabbage, showing its effectiveness in assessing topographically challenging surfaces – but with its ability to analyze biofluids and metabolites, LAESI also has potential in pharma and biosciences.
Credit: Benjamin Bartels Reference: B Bartels et al., RSC Adv, 7, 9045-9050 (2017).
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