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Techniques & Tools Mass Spectrometry, Metabolomics & Lipidomics

METLIN at 500K

The Problem

As metabolomics took off in the early 2000s, it became increasingly clear that GC-MS data was hampered by its 1950s-era electron ionization – using a single designated ionization energywith the need for derivatization – and a focus on molecules that are stable enough to survive the GC oven. An alternative was needed – one that could harness the emerging power of MS/MS techniques.

Background

For decades, GC-MS was the dominant metabolite and small molecule identification technology, despite its drawbacks. This dominance was primarily due to the impressive size of its chemical libraries; for example, NIST’s library of GC-MS mass spectra, which contained information for over 270,000 individual compounds.

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About the Author

Gary Siuzdak

Gary Siuzdak is Professor and Director of the Scripps Center for Metabolomics at the Scripps Research Institute, La Jolla, California, USA.

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