Cookies

Like most websites The Analytical Scientist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Techniques & Tools Technology, Spectroscopy

SERS SLIPS Ahead

Surface-enhanced Raman scattering (SERS) has high molecular specificity and high sensitivity, but its applicability is limited by a reliance on aqueous solvents for extraction and poor performance in heavily diluted solutions. Now, researchers from Pennsylvania State University have combined SERS with slippery liquid-infused porous surfaces (SLIPS) to create... You guessed it: SLIPSERS (1). We spoke with Tak Sing Wong, Assistant Professor of Mechanical Engineering and lead author of the study, to find out how they’re addressing the limitations of SERS.

Why focus on SERS?

SERS is a very powerful platform for molecular diagnostics and analysis. However, there are two important roadblocks that limit its practical application. First, SERS detection in liquid media relies on highly statistical binding of analytes to the SERS-sensitive regions (or “hot spots”) because of the diffusive nature of the analytes. As a result, it is very challenging to achieve single-molecule detection in highly diluted solutions. Second, many real-life analytes may be dispersed in liquid or gas phases or may be bound to solid substrates (for example, soil), which may require the use of non-aqueous solvents for extraction.

Read the full article now

Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE and always will be!

Login

Or register now - it’s free and always will be!

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Analytical Scientist magazine
Register

Or Login via Social Media

By clicking on any of the above social media links, you are agreeing to our Privacy Notice.

About the Author

Tak Sing Wong

Assistant Professor of Mechanical Engineering and lead author of the study.

Register to The Analytical Scientist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:

  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Analytical Scientist magazine

Register