Taking MALDI to the Next Level
The rise of MALDI has historically been hampered by inherent challenges – fresh innovations could open the door to new application areas and opportunities
Shannon Cornett | | Opinion
I think it’s fair to say that MALDI-MS imaging has been a transformative technique when it comes to understanding the molecular makeup and regional heterogeneity of biological tissues. Its label-free nature and ability to differentiate compounds by molecular weight make it suitable for many applications – from drug discovery to pathology and biomedical research.
And yet, it’s also fair to argue that MALDI imaging faces inherent challenges – namely, ion suppression, sensitivity at higher spatial resolutions, and quantification dynamic range –which technological advances have failed to address. Until now.
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