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Techniques & Tools Mass Spectrometry, Pharma & Biopharma

Taking MALDI to the Next Level

I think it’s fair to say that MALDI-MS imaging has been a transformative technique when it comes to understanding the molecular makeup and regional heterogeneity of biological tissues. Its label-free nature and ability to differentiate compounds by molecular weight make it suitable for many applications – from drug discovery to pathology and biomedical research.

And yet, it’s also fair to argue that MALDI imaging faces inherent challenges – namely, ion suppression, sensitivity at higher spatial resolutions, and quantification dynamic range –which technological advances have failed to address. Until now.

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About the Author

Shannon Cornett

Global MS Imaging Market Manager, Bruker Daltonics, Billerica, MA, USA

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