The Innovators 2024

Showcasing the products and companies making a difference in 2024

12/09/2024

The Spectrus JS family brings the tools and capabilities scientists have long relied on and loved to the browser

^{Sponsored by ACD/Labs}

The devices and apps we use in our personal lives have fundamentally changed our expectations of the software we use at work. Analytical chemistry software helps us extract answers from complex datasets to support decision-making and risk-management, provides proof for regulatory filings, fosters innovation through knowledge management and collaboration, and much more. While there has been a transition from software that’s dedicated to the instrument, most analytical chemistry software is still limited to desktop applications. These have traditionally offered performance advantages and are independent from an internet connection, but modern IT infrastructure severely narrows this gap.

The Spectrus JS family of applications bring accessible data and modern user-friendly interfaces to the lab – or wherever scientists want to access and work with their data! The JavaScript-based applications are optimized for handling NMR, LC/UV/MS, and other analytical data along with chemical information. They leverage Spectrus Platform technology to render detailed chemical and analytical data in a web environment, bypassing platform constraints that typically accompany legacy software. Spectrus JS provides realtime interaction and reporting of complex datasets through standard web browsers. Users can explore data and process/reprocess without locally installed software. This functionality is achieved through advanced algorithms that convert analytical data from all major vendor formats for seamless visualization and interaction. Users experience high performance and precision with data integrity and traceability. Spectrus applications ensure that critical scientific insights are preserved and shared accurately. Spectrus JS also makes it easier for scientists and data scientists to collaborate seamlessly – an important factor in the modern R&D enterprise.

Spectrus JS is essential for the digital transformation of analytical labs. It provides simple deployment without download and installation on individual machines or networks; easy scalability, updates, and maintenance; and seamless integration with existing informatics systems via API. Spectrus JS facilitates data preparation, assembly, and validation, ensuring that analytical and contextual chemical data can be used in multi-platform environments and AI-enabled workflows. This is a critical need as data volumes and complexity grow. Furthermore, as R&D budgets and IT teams are stretched, web-based Spectrus JS enables the use of powerful, expert software on machines with low RAM and processing power.

As ACD/Labs continues to evolve its Spectrus software portfolio to web-based applications, analytical scientists will gain the freedom to work with their data with fewer restrictions and be able to collaborate seamlessly. R&D organizations will be able to leverage the data generated in analytical labs easier than ever before.

Push the boundaries of discovery and innovation with The VARIUS™ Spectrometer from Avantes. Unlock precision and real-time analysis today.

^{Sponsored by Avantes}

Discover a new era of precision with the VARIUS™ Spectrometer, an innovation in spectroscopy designed to meet the highest standards of accuracy. Its advanced optical design guarantees unmatched sensitivity and resolution across a broad spectral range, spanning from 190 to 1100 nm.

What distinguishes the VARIUS™ is its versatility. Whether you’re exploring biological molecules, nanomaterials, or monitoring environmental pollutants, its modular design effortlessly adapts to various sampling accessories. Enjoy seamless connectivity and data management through intuitive software, simplifying integration into your laboratory setup – empowering researchers, scientists, and educators to push the boundaries of knowledge.

The VARIUS™ offers superior signal-to-noise ratios, minimal stray light (0.1 - 1 percent), and integration times ranging from 9 μs to 30 seconds. It connects seamlessly via USB 3.0 and Gigabit Ethernet interfaces, delivering lightning-fast data transfer speeds. Compact and sleek, weighing just 1,068 grams, it seamlessly fits into your lab setup.

Experience spectroscopy redefined with the VARIUS™ Spectrometer – where versatility meets precision. Discover the VARIUS™ and empower your research or application today!

Michel Klein Gunnewiek, Application engineer, Avantes

I studied analytical chemistry at Saxion, before moving on to chemical engineering at the University of Twente. There, I focused on material science – a field I worked in for seven years before circling back to analytical science. Having a background in both materials science and analytical chemistry really helps me look at problems from different angles, which is certainly helpful in my current role at Avantes.

At Avantes, we are constantly investing in R&D to improve our spectrometers and come up with new ways to make our devices work for different applications. Whether it’s making sensors more sensitive or making instruments smaller and more portable. We do this, driven by our company mission: to empower our customers to drive innovation forward in their area of expertise, with the help of our spectroscopy solutions.

One big lesson is that innovation doesn’t always mean huge breakthroughs. It also comes from small, steady improvements and learning from each version. Every time we change a design or get feedback on a new application, we learn something valuable. The little things add up over time, and it’s important to keep that mindset of continuous learning.

I think analytical instrumentation is going to become even more integrated into everyday industrial and environmental processes. Instead of being limited to labs, I expect tools like spectrometers to be increasingly used in factories, farms, and other real-world settings, where they can provide instant data that helps optimize processes.

The Intabio ZT system couples icIEF separation and UV detection with high-resolution mass spectrometry for peak identification

^{Sponsored by SCIEX}

The process of identifying proteoforms in individual charge variant peaks and interpreting their structural differences conventionally takes weeks and requires the use of multiple instruments, with multiple steps. With the Intabio ZT system, separation, quantitation and identification of individual charge variants can be achieved in minutes on a single integrated platform.

Support high throughput analysis with 15-minute separation and enable detailed characterization on charge variant peaks of multiple monoclonal antibodies without redundant method development or fraction collection.

Identify common critical quality attributes (CQAs) like glycosylation, deamidation and glycation.

Achieve high-resolution separation and identification of proteoforms with as little as 0.02 pI value difference.

Maintain data continuity with a single workflow producing one, accessible dataset, where UV peaks correlate with MS peaks.

Learn more about the Intabio ZT system: https://sciex.li/z59ngc

Scott Mack, Principal Scientist, SCIEX

My first industrial post after graduating with a degree in Biochemistry was for an Assay Development and Implementation group supporting the testing of in silico-designed proteins. In the twenty years since then, I have expanded my research focus to include genomics, reagents, software, hardware and analytics.

When it comes to the development of biologic therapeutics, one of the greatest limitations is the current cost structure required to collect data and make informed decisions. The Intabio ZT system uses icIEF-UV/MS to radically reduce the resource intensity required for characterizing and identifying therapeutic proteoforms, allowing for unprecedented decision-making efficiency at every step in the product development lifecycle.

Collaboration is essential for innovation. The Intabio ZT system would not exist without the breakthrough contributions of at least a half dozen individuals. In my experience, members from the most innovative teams are looking to champion the best solutions rather than always promoting their own concepts.

I see the continued development of automation in instrument operation and analytics to reduce both researcher workloads and results variation. New instrument functionality and flexibility can be realized through the adaptation of microfluidic technologies, especially in the advancement of multidimensional analysis along with sample-to-result workflows.

Use advanced triple detection to analyse the structure, shape, and conformation of polymers

^{Sponsored by TOSOH}

The LenS3™ MALS-V detector is a dual detector for size exclusion chromatography (SEC) integrating multi-angle light scattering (MALS) and viscometry. Combined with the EcoSEC Elite GPC system and TSKgel columns, it offers a complete and cost-effective approach for triple detection analysis.

In a triple-detection SEC setup, the refractive index detector gauges concentration, MALS provides true molecular weight and radius of gyration, while the viscometer measures intrinsic viscosity. The intrinsic viscosity of polymers reflects how dense and how flexible polymer chains are in dilute solutions. The lower the intrinsic viscosity, the more compact the polymer. Rigid polymer chains show a higher intrinsic viscosity than flexible random coils. Applying triple detection GPC thus provides you with a comprehensive picture of your sample.

The detector comes with the most advanced triple detection GPC/SEC software on the market. SECview™ software includes seamless MALS and viscometry data acquisition and processing to get the most out of advanced detection GPC/SEC analyses.

Snežana Đorđević, Application Scientist Analytical Instruments, Tosoh Bioscience

With a background in pharmacy and analytical chemistry, I have dedicated my career to merging my skills into polymer characterization techniques. The possibility of creating something new with widespread application in a very creative way was why I have choosen Application Scientist as the next role in my carrier. I am now dedicating my time to finding new applications of GPC in polymer characterization.

My career path has trained me to ask questions, understand the answers, make conclusions, and provide solutions that will be useful not only to me but to my team and society. My multidisciplinary backgound has made me aware of how important it is to have a profound understanding of any analyte that requires characterization (including polymers), which can lead an analytical chemist to generate new ideas or optimize protocols.

We’re seeing an increasing number of new polymer types, which are getting more difficult to characterize. Technology must keep pace with this rapidly growing field: we require innovation to improve detector sensitivity and versatility so that we may obtain accurate and reproducible data.

Trust your ideas, no matter how crazy they may sound, but also consult multidisciplinary experts to help you make those ideas reality.

By collaborating with academics and companies we can share our expertise in SEC and help them answer their research questions; in return, they provide us with important feedback on our products – whether it be improving data analysis or column design.

Email*

Choose a password*

I have read and understand the Privacy Notice *

Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

Receive communication from The Cannabis Scientist I want to stay up to date with the Mass Spectrometry field I want to stay up to date with the Spectroscopy field

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.