We’re (re)developing twin column “recycling” chromatography as a semi-preparative technology that separates and identifies trace impurities.
The problem originates from the pharmaceutical industry: the need to unambiguously identify trace impurities that nearly co-elute with the main active pharmaceutical ingredient (API). The identification can be easily achieved by nuclear magnetic resonance (NMR) spectroscopy, but it requires that about 1 mg of the impurity be prepared at a purity level of at least 90 percent. Given the current state of instrumentation, the pharma industry could not find acceptable technologies capable of producing a (nearly) co-eluting trace impurity at this level within a reasonable timeframe – either because of a lack of resolution power (semi-prep instruments, see Figure 1) or a low production rate (analytical instruments). An alternative semi-prep technology is therefore desperately needed to solve this problem.
Enjoy our FREE content!
Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE and always will be!
Login if you already created an account
Or register now - it’s free and always will be!
You will benefit from:
- Unlimited access to ALL articles
- News, interviews & opinions from leading industry experts
- Receive print (and PDF) copies of The Analytical Scientist magazine