Accurate Sizing and Precise Counting of 10 nm Gold Nanoparticles using the Enhanced Sensitivity of the NexION 2000 ICP-MS
contributed by Perkin Elmer |
The rapid development and implementation of nanomaterials in various consumer products has created the need to rapidly and accurately characterize nanoparticles (NPs) of various sizes and compositions. A number of techniques are available for the measurement of metal and metal-containing NPs, but all suffer from limitations1. The development of Single Particle ICP-MS (SP-ICP-MS) has overcome many of these limitations, and it has been well-documented as a technique to rapidly measure, count, and characterize metallic and metal-containing nanoparticles and/or nanomaterials2-8. According to the European Commission (EC) Recommendation (2011/696/EU), “nanomaterials” are defined as any “natural, incidental or manufactured material containing particles in an unbound state or as an aggregate or agglomerate and where, for 50% or more of the particles in the number size distribution, one or more external dimensions is in the size range 1 nm–100 nm”9. Traditionally, one of the challenges of nanoparticle (NP) analysis by SP-ICP-MS is the ability to accurately characterize particles that are smaller than 20 nm10.
Read the full article now
Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE!