ALEXYS Neurotransmitter Analyzer for Monoamines and their Acidic Metabolites

07/31/2018

Over the last few years, many papers have appeared on improving the speed of separation and/or analyzing small sample volumes at low detection limits. In this application note a fast UHPLC method for noradrenaline (NA), dopamine (DA) and serotonin (5-HT), and their metabolites homovanillic acid (HVA), 5-hydroxyindole acetic acid (5-HIAA), and 3,4-dihydroxyphenylacetic acid (DOPAC) is presented with electrochemical detection (ECD). The concentrations of NA, DA and 5-HT in microdialysis fractions can be below 100 pmol/L. In combination with a small sample volume of a few microliters, this requires an extremely low limit of detection down to the range of 0.1 – 0.5 fmol on column. These low LOD’s are accessible with the ALEXYS Neurotransmitter Analyzer.

Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE!

Email*

Choose a password*

I have read and understand the Privacy Notice *

Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

Receive communication from The Cannabis Scientist I want to stay up to date with the Mass Spectrometry field I want to stay up to date with the Spectroscopy field

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.