ALEXYS Neurotransmitter Analyzer for Monoamines and their Acidic Metabolites

07/31/2018

Over the last few years, many papers have appeared on improving the speed of separation and/or analyzing small sample volumes at low detection limits. In this application note a fast UHPLC method for noradrenaline (NA), dopamine (DA) and serotonin (5-HT), and their metabolites homovanillic acid (HVA), 5-hydroxyindole acetic acid (5-HIAA), and 3,4-dihydroxyphenylacetic acid (DOPAC) is presented with electrochemical detection (ECD). The concentrations of NA, DA and 5-HT in microdialysis fractions can be below 100 pmol/L. In combination with a small sample volume of a few microliters, this requires an extremely low limit of detection down to the range of 0.1 – 0.5 fmol on column. These low LOD’s are accessible with the ALEXYS Neurotransmitter Analyzer.

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