App Notes

How to screen 100s of pesticides in 13 unknown Food Samples – in 3 minutes

As the demand for testing of pain management drugs increases, many laboratories are turning to LC-MS/MS for its increased speed, sensitivity, and specificity. The methods shown here use a Raptor™ Biphenyl column because it provides fast, accurate analysis of 231 drugs and drug metabolites.

This application describes the use of ISOLUTE SLE+ for ultra-sensitive determination of 1,25 di-OH Vitamins D2 and D3.

In recent years a lot of research has been done on the medicinal use of Cannabis sativa. The shown method is suitable for confirmation of the cannabinoids CBN, CBD and THC by High-Performance Thin-Layer Chromatography coupled with a mass detector.

This application note demonstrates the advantages of the new diode array detector AZURA® DAD 2.1L.

In this AppNote, automated fractionation of lipid classes using solid phase extraction (SPE) is presented. The SPE fractions are concentrated and re-dissolved in small amounts of solvent, followed by LC-QTOF analysis.

This Application Note describes analysis of ppt-level PAHs in ambient air, using pumped sampling, thermal desorption, and gas chromatography. Using optimised sorbent sampling tubes, the method offers greater sensitivity compared to labour-intensive solvent-extraction protocols employed in many standardised methods.

Hydrophobic interaction chromatography (HIC), a technique commonly used for protein separation, is also used as an orthogonal method to size-exclusion and ion-exchange chromatography for the characterization of monoclonal antibodies and antibody-drug conjugates.

This application note describes the extraction of acidic, basic, and neutral drugs from urine for screening purposes using ISOLUTE® SLE+ supported liquid extraction plates prior to LC-MS/MS analysis.

Researchers from Prof. Guido Verbeck’s group at the University of North Texas (UNT) carried out analysis of drugs of abuse (DOA) and explosives using an ion trap GC-MS to compare results when using helium and hydrogen carrier and buffer gas.