Analyzing the Underworld: a Legal High
How a respectable chiral separation scientist got sucked into the weird, wonderful, and unpredictable field of novel psychoactive substances.
Martin Schmid | | Longer Read
Almost a decade ago, I’d never really given a second thought to how the scope of my analytical research might change in the future. But change it did!
Back in 2010, I was a senior scientist at Graz University. I developed chiral separation methods for active pharmaceutical ingredients, using various high-performance separation techniques, including HPLC, GC, capillary electrophoresis, and capillary electrochromatography – all highly respectable. My former supervisor was retiring, and I was charged with taking over his lessons. I felt that one of those lessons – the analysis of illicit drugs – could do with a little more “spice.” But how?
Read the full article now
Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE and always will be!
Or register now - it’s free and always will be!
You will benefit from:
- Unlimited access to ALL articles
- News, interviews & opinions from leading industry experts
- Receive print (and PDF) copies of The Analytical Scientist magazine
Or Login via Social Media
By clicking on any of the above social media links, you are agreeing to our Privacy Notice.
- M Taschwer, Y Seidl, S Mohr and MG Schmid, “Chiral separation of cathinone and amphetamine derivatives by HPLC/UV using sulfated ß-cyclodextrin as chiral mobile phase additive”, Chirality, 26, 411–418 (2014). DOI: 10.1002/chir.22341.
- S Mohr, JA Weiß, J Spreitz , MG Schmid, “Chiral separation of new cathinone- and amphetamine-related designer drugs by gas chromatography-mass spectrometry using trifluoroacetyl-L-prolyl chloride as chiral derivatization reagent”, J Chromatogr A, 1269, 352–359 (2012).
- JAWeiß, M Taschwer, S Mohr and MG Schmid, “Indirect chiral separation of new recreational drugs by gas chromatography-mass spectrometry using trifluoroacetyl-L-prolyl chloride as chiral derivatization reagent”, Chirality, 27, 211–215 (2015).
- K Kalíková, M Martínková, MG Schmid and E Tesařová, “Cellulose tris-(3,5-dimethylphenylcarbamate)-based chiral stationary phase for the enantioseparation of drugs in supercritical fluid chromatography: comparison with HPLC”, J Sep Sci, 41, 1471–1478 (2018).
- Z Aturki, MG Schmid, B Chankvetadze and S Fanali, “Enantiomeric separation of new cathinone derivatives designer drugs by capillary electrochromatography using a chiral stationary phase, based on amylose tris(5-chloro-2-methylphenylcarbamate)”, Electrophoresis, 35, 3242–3249 (2014).
- D Albalsa et al, “Chiral separations of cathinone and amphetamine-derivatives: Comparative study between capillary electrochromatography, supercritical fluid chromatography and three liquid chromatographic modes”, J Pharm Biomed Anal, 121, 232–243 (2016).
- M Taschwer, J Grascher and MG Schmid, “Development of an enantioseparation method for novel psychoactive drugs by HPLC using a Lux1 Cellulose-2 column in polar organic phase mode”, Forensic Sci Int, 270, 232–240 (2017).
- K Kadkhodaei, L Forcher, and MG Schmid, “Separation of enantiomers of new psychoactive substances by high-performance liquid chromatography”, J Sep Sci, 41,1274–1286 (2018).
- S Mohr, S Pilaj, and MG Schmid, “Chiral separation of cathinone derivatives used as recreational drugs by cyclodextrin-modified capillary electrophoresis”, Electrophoresis, 33,1624–1630 (2012).
- M Taschwer, MG Hofer and MG Schmid, “Enantioseparation of benzofurys and other novel psychoactive compounds by CE and sulfobutylether β-cyclodextrin as chiral selector added to the BGE”, Electrophoresis, 35, 2793-2799 (2014).
- JS Hägele and MG Schmid, “Enantiomeric separation of novel psychoactive substances by capillary electrophoresis using (+)‐18‐crown‐6‐ tetracarboxylic acid as chiral selector”, Chirality, 30, 1019–1026, (2018). DOI: 10.1002/chir.22981