Biomarkers Beyond Our Wildest Dreams
Could glycosylation patterns associated with a sleep behavior disorder predict the onset of neurodegenerative disease?
Luke Turner | | Quick Read
For someone with idiopathic REM sleep behavior disorder (iRBD), dreams can come true – literally. A loss of muscle paralysis during rapid eye movement (REM) sleep can cause patients with the disorder to physically act out their dreams. There is a pressing need to identify biomarkers that could help diagnose this condition – not just because the disorder itself can affect overall health, but also because iRBD is now considered to be an early indicator of an α-synucleinopathy related to various neurodegenerative diseases, such as Parkinson’s. Now, research that focuses on glycosylation patterns has identified certain N-glycan structures that could serve as diagnostic biomarkers for patients with iRBD (1).
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- X Dong et al., “LC-MS/MS glycomics of idiopathic rapid eye movement sleep behavior disorder”, Electrophoresis, 39, 3096–3103 (2018). PMID: 30168606.