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Fields & Applications Metabolomics & Lipidomics, Liquid Chromatography, Mass Spectrometry

Biomarkers Beyond Our Wildest Dreams

For someone with idiopathic REM sleep behavior disorder (iRBD), dreams can come true – literally. A loss of muscle paralysis during rapid eye movement (REM) sleep can cause patients with the disorder to physically act out their dreams. There is a pressing need to identify biomarkers that could help diagnose this condition – not just because the disorder itself can affect overall health, but also because iRBD is now considered to be an early indicator of an α-synucleinopathy related to various neurodegenerative diseases, such as Parkinson’s. Now, research that focuses on glycosylation patterns has identified certain N-glycan structures that could serve as diagnostic biomarkers for patients with iRBD (1).

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  1. X Dong et al., “LC-MS/MS glycomics of idiopathic rapid eye movement sleep behavior disorder”, Electrophoresis, 39, 3096–3103 (2018). PMID: 30168606.

About the Author

Luke Turner

While completing my undergraduate degree in Biology, I soon discovered that my passion and strength was for writing about science rather than working in the lab. My master’s degree in Science Communication allowed me to develop my science writing skills and I was lucky enough to come to Texere Publishing straight from University. Here I am given the opportunity to write about cutting edge research and engage with leading scientists, while also being part of a fantastic team!

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