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Fields & Applications COVID-19, Clinical, Mass Spectrometry, Proteomics

Gelling with MS-Based Diagnosis

The use of MS-based proteomics for clinical diagnosis is steadily increasing – and COVID-19 has only accelerated its adoption for viral infections. But the traditional sample pretreatment methods required for these analyses take over 20 hours and there are still challenges around peptide recovery and reproducibility of results. 

Now, researchers have developed a novel approach, termed BAC-DROP, that could help overcome some of these issues. First, the proteins are fractionated at high resolution; then, the gel itself is dissolved to release any fragments that have escaped before proceeding to MS quantification. The team have demonstrated the technique’s successful incorporation into MS-based testing of clinical samples, such as hepatitis B virus. With MS-based diagnosis on the rise, this high-throughput sample preparation approach could help with translation to the clinical lab.

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  1. A Takemori et al., J Proteome Res, 20, 1535 (2021). DOI: 10.1021/acs.jproteome.0c00749
About the Author
Lauren Robertson

By the time I finished my degree in Microbiology I had come to one conclusion – I did not want to work in a lab. Instead, I decided to move to the south of Spain to teach English. After two brilliant years, I realized that I missed science, and what I really enjoyed was communicating scientific ideas – whether that be to four-year-olds or mature professionals. On returning to England I landed a role in science writing and found it combined my passions perfectly. Now at Texere, I get to hone these skills every day by writing about the latest research in an exciting, creative way.

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